Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]
It even fine-tunes proteins through a process called S-glutathionylation , which can protect enzymes, adjust their function, or prevent further damage
Slightly more MEHP leached from PVC 48d compared to PVC 24d , due to the higher initial MEHP content ( p = 2.95 10 5 , Table S2.4) in PVC 48d
Ferroptosis is an iron-dependent, lipid peroxidation-driven cell death process characterized by glutathione (GSH) depletion and inactivation of glutathione peroxidase 4 (GPX4), leading to the accumulation of lipid peroxidation products (e.g., MDA and LPO) and cell membrane rupture, hallmark features include mitochondrial alterations (e.g., reduced cristae and increased membrane density), elevated lipid peroxidation, and dysregulated iron metabolism (Jiang et al
Investigations by magnetic spectroscopies
Kalyakulina, A
