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iii) High risk: Three or more criteria rated as unclear or at least two criteria not met

doi:10.1007/s11695-017-3102-y

Vitamin B12 Enhances Good Mood and Helps Fight Depression Vitamin B12 is essential for the function of the brain, mood, and serotonin synthesis

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers