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GH deficiency support FDA-approved as somatropin for growth hormone deficiency in children and adults one of its established clinical indications

Mood modulation - separate studies examine a potential link with serotonergic regulation

Its half-life is generally considered relatively short, often around a few hours or less

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Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)