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Of note, conditional inducible deletion of GPX4 in neurons results in neurodegeneration consecutive to rapid cell death [6]

Consider avoiding things that increase (i.e., induce) CYP1b1 and CYP3a4 enzymatic activity Recall that CYP1b1 is the enzyme that converts estrogen to the 4-OH metabolites and CYP3a4 is the enzyme that converts estrone (E1) to the 16-OH-E1 metabolite, and estradiol (E2) to estriol (E3)

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499 Additionally, leveraging the dynamic changes of targets may be a potential strategy for developing selective inhibitors

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