2 Major chemical components and pharmacological effects of Scrophulariae Radix 2.1 Major chemical components Scrophulariae Radix , a well-known TCM, contains various active constituents, including iridoids, phenylpropanoids, organic acids, volatile oils, steroids, carbohydrates, flavonoids, alkaloids, and phenols
Among them, C-X-C motif chemokine ligand 1 and 2 (CXCL1 and CXCL2) are significantly upregulated in lesional skin and primarily mediate neutrophil recruitment through interaction with the CXCR2 receptor, thereby aggravating tissue damage and acute symptoms such as erythema and edema (Sakai et al., 2021)
In practice, these interdependent parameters are tuned in combination to achieve the desired in vivo behavior and provide the physical and pharmacokinetic scaffold on which more specialized functional units can be built
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Akhtar A, Andleeb A, Waris TS, Bazzar M, Moradi A-R, Awan NR, Yar M
The LASSO Cox model stratified patients into high-risk and low-risk groups with significantly different DFS
