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24 Decreased expression or inhibition of CYP2A6 activity reduces nicotine metabolism and has been suggested as a primary target for tobacco cessation strategies, resulting in a reduction of the number of cigarettes necessary for a smoker to maintain a given nicotine level leading to diminished smoking overall

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1 While tobacco use has declined, 30 million people continue to smoke, making cessation a focus for cardiovascular clinicians

At the time, the space was mostly used by celebrities and their entourages on trips between Europe and the United States - virtually the only people who could afford to travel in this manner