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The synovium primarily consists of FLSs and immune cells

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype

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If you hit a nerve or a blood vessel, or you introduce an air bubble into your vasculature, youre going to end up potentially doing serious, if not life-ending damage. Taylor adds that there is even some suggestion that these substances could activate pathways used by cancers to attack the body although he stresses that this has not been proven with direct evidence