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Influence on stress response regulation systems

PMID: 30090586 Heard KJ

As General Manager of a specialty chemicals company and Director of Operations for a biotechnology firm, he honed his expertise in scientific innovation, project management, and health improvement

Pernicious anaemia, an autoimmune loss of intrinsic factor, is the classic one

In a controlled study, healthy volunteers received a low dose of Escherichia coli endotoxin to induce experimental low-grade inflammation

By integrating transcriptomic and untargeted metabolomic analyses of BM neutrophils, we revealed a pivotal role for Chac2-driven GSH metabolic reprogramming in skewing neutrophils toward the N1 phenotype, which is orchestrated by upstream IFN-I signaling