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For more information on B-vitamin safety, the Linus Pauling Institute at Oregon State University is a great resource
doi: 10.1038/s41416-019-0717-x 193 SilvaAAntunesBBatistaAPinto-RibeiroFBaltazarFAfonsoJ
Concurrent use of nicorandil and PDE5Is is contraindicated due to the potential of the nitric oxide donating properties of nicorandil to increase cGMP levels [422]
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