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The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation

Therefore, researchers should not interpret them as human dose targets, blood concentrations, or safety thresholds

For sustained weight loss, pair interventions: nutrition, behavior change, progressive activity, and, where suitable, medications or supplements backed by trials

It also increases the body's ability to use fat for energy while slowing down the process that converts excess calories into fat

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