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Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71

Pain Physician 22 (1): E45e52

however, details on the studies are limited and are not overly informative

Treatment recommendations are individualized and require medical evaluation

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The Michigan Neuropathy Screening Instrument (MNSI) emphasizes foot inspection and vibration testing, with reported sensitivity of 80% and specificity of 95% versus NDSs 75% and 82%