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Gerry Fegan, Yeap BB, et al

In addition to these established topical options, emerging evidence suggests that topical amitriptyline may provide clinically meaningful pain relief with acceptable tolerability in BMS, whereas topical doxepin has demonstrated analgesic efficacy in head-and-neck mucositis pain in randomized trials 19,20

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There is no robust evidence that sublingual preparations offer a clinically meaningful advantage over standard oral tablets at equivalent doses

doi: 10.1146/annurev-animal-020518-115239 142 JabariASadighi GilaniMAKorujiMGholamiKMohsenzadehMRastegarTet al