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Studies have shown an intriguing regulation of GHR signaling by IGF-1R, which suggested that IGF-1R positively regulates GH-mediated signaling by preventing PTP-1B suppression of GH activation of STAT5 (144)

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For nerve-specific applications, subcutaneous injection near the affected area (when accessible) may offer advantages over distant-site injection, though systemic administration also shows efficacy in the published research

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