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In an observational study, individuals that have T2DM, GLP-1RA therapy, Liraglutide, reduced pro-inflammatory cytokines (e.g., TNF-, interleukin-1 beta (IL-1), IL-6) in PBMCs, and increased serum adipokine, adiponectin, and macrophage activation markers (sCD163) [95]

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*Vitamin B12* is also essential for DNA synthesis and energy production

Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1)

Overall, older people have a higher incidence of SIBO due to poorer gastrointestinal function, which could lead to an indirect association between PPI and SIBO (Rao and Bhagatwala, 2019)

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