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doi: 10.1002/mrd.10102 39 HarrisSELeeseHJGosdenRGPictonHM

NAC appears to exert its biological activity by acting as a precursor of glutathione, a ubiquitous compound with anti-oxidant properties that is involved in the metabolism of xenobiotics, signal transduction and gene expression, regulation of the cell cycle and apoptosis, and prostaglandin and leukotriene synthesis, among other processes [1, 2]

Motzer RJ, Tannir NM, and McDermott DF, et al (2018) Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma N Engl J Med 378 (14) 12771290 PMID: 29562145 PMCID: 5972549 8

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