This inhibitory effect escalated concomitantly with increasing drug loading
Oversecretion of aldosterone ( hyperaldosteronism ) by the adrenal glands can also interfere with water and sodium retention by the kidney and has been associated with treatment-resistant hypertension (Calhoun 2013
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Activation of pancreatic enzymes exacerbates necrosis, damages endothelial cells, and induces edema, hypoxia, and organ failure [19,20,21]
