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Clinical risk factors variables included age, systolic and diastolic blood pressure, glycated hemoglobin levels, fasting cholesterol levels, smoking status and waist circumference as described 31

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Niacinamide is one of two major forms of vitamin B3, the other being niacin (nicotinic acid)

Hypothyroidism may impact 5% of Americans, with another 5% estimated to be undiagnosed but still experiencing symptoms

Copper is an essential trace element that participates as a cofactor in numerous enzymes (including superoxide dismutase, cytochrome c oxidase, and lysyl oxidase) and in regulatory roles where its redox activity and metal-binding properties become biologically consequential

doi: 10.3390/biology12060800