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Vitamin B12 is one of those vitamins that are only really naturally attained through diet, making anyone who has dietary restrictions or trouble absorbing vitamins through diet alone at risk of suffering from a deficiency

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When this information is absent from Box 19 of the CMS-1500 or the 837P equivalent, the claim will be denied as incomplete

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In each, B12 status can be impaired even when the total level looks adequate

Nur E, Verwijs M, de Waart DR, Schnog JJ, Otten HM, Brandjes DP, Biemond BJ, Elferink RP, CURAMA Study Group (2011) Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes