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Exposure to Mitomycin C (MMC) has been shown to increase ROS production in RA-FLS and disrupt m, increasing the release of mitochondrial cytochrome c and the ratio of Bax/Bcl-2 and inducing apoptosis in RA-FLS (130)
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Having one or more of these polymorphisms is associated with an increased risk of certain diseases, especially when impacted by environmental triggers such as pollution, smoking, heavy metals, and other toxins