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Further, SARS-CoV activates NLRP3 inflammasome, which upregulates the expression of IL1 and IL18 proinflammatory cytokines in lipopolysaccharide (LPS)-primed macrophages via 3a protein (also known as 3a-NLRP3-IL1b) signaling axis [55]

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This preparatory work constituted the foundation for the subsequent qualitative and quantitative research to develop further and examine the psychometric properties of the new measure

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