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Certain Cancers: Blood cancers, such as leukaemia, may increase B12 levels in the blood 4 , 11

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The technique allows precise staging of the depth of invasion into the mucosa or submucosa (with better interobserver agreement between pathologists in grading dysplasia than with biopsies) and the assessment of margins, and it may be therapeutic if lateral and deep margins are clear (Figure 2.8)

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