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Although many receptors take part in endocannabinoid signaling [e.g., peroxisome proliferator-activated receptors (PPARs), transient receptor potential cation channels (TRPs)], the two main cannabinoid receptors are cannabinoid receptor type 1 (CB 1 R) and cannabinoid receptor type 2 (CB 2 R

The primary long-term concern is cofactor depletion glutathione relies on zinc and selenium for its antioxidant enzyme systems, and prolonged high-dose use (beyond 12 weeks) can deplete these minerals, potentially causing fatigue or immune suppression

Alberts JF, Engelbrecht Y, Steyn PS, Holzapfel WH, van Zyl WH (2006) Biological degradation of aflatoxin B1 by Rhodococcus erythropolis cultures

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Hierarchical clustering analysis was used to visualize these differentially abundant metabolites

J Cell Biochem 2000