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Trends Endocrinol Metab 28 (5), 340353

23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

When will I notice the effects of B12

The effect of vitamin B12 can often be noticed within two or three days, and maximum benefits may be seen with continued use after more than three months

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How often you need B12 depends on why you are having it