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however, they were non significant for their combinations

Agents that cause depletion of catecholamines from the sympathetic nerve terminals (e.g., reserpine) can also antagonize indirectly acting agents (such as tyramine) because there is a lack of catecholamines to be released

The active comparator arms lost 14.9 per cent on semaglutide alone and 11.5 per cent on cagrilintide alone, evidence of genuine additive benefit from the combination

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