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IGF-1 promotes cell proliferation and tissue growth, which raises theoretical concerns about tumor growth or cancer risk, especially in individuals with pre-existing tumors or a family history of cancer

Thus, it is essential to define adipocyte-intrinsic transcriptional regulators that recruit immune cells to AT to find novel druggable targets

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Important caveat: the evidence for these mechanisms and benefits is preclinical based on cell and animal studies

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis

Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency