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The data is earlier-stage and most of the human work comes from outside the U.S
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[DOI] [PubMed] [Google Scholar] Volz TJ
Consequently, antioxidant interventions have not yet been incorporated into clinical guidelines ( 7.3 Challenges in standardizing EV isolation, characterization, and validation For EV-based therapies, major challenges arise from the lack of standardized isolation and characterization protocols
Regarding MAPK1 and MAPK3, studies have reported that they are involved in BRCA through several approaches, including the activation of cell cycle-related proteins and inhibition of antiapoptotic proteins by MAPK1/MAPK3 phosphorylation, and regulation of cytoskeletal proteins to promote migration 36
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