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Additionally, the distinction between tobacco and cannabis or CBD-containing products is not always legally distinct

31,82 Recent work shows that cigarette smoke extract can worsen cartilage degeneration and induce apoptosis, oxidative stress, mitochondrial dysfunction, and matrix abnormalities in OA chondrocytes, while TNF- inhibition may partly reduce these effects

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If passed, the city expects the tax to generate $83 million in a first full year of collections, which would go a long way to filling a budget gap that threatens to cause mass layoffs

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