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Autophagy is divided into macroautophagy (usually called autophagy), microautophagy, and molecular chaperone-mediated autophagy (Rubinsztein et al., 2005), but in situations such as starvation, ischemia, hypoxia, protein misfolding, or damage to organelles, autophagy will be activated to maintain cell homeostasis (Yorimitsu and Klionsky, 2005
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One major challenge is the physical barrier imposed by airway mucus 10,115 , which traps and clears all inhaled foreign particles indistinctively through MCC 116