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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]

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Finally, as revealed in grafting and feeding experiments in vivo , GTR1 and GTR2 are likely to also be involved in bidirectional distribution of GSLs between the roots and rosettes, substantiating the role of both phloem and xylem as their transport pathways ( The NRT/PTRs constitute a large plant transporter family belonging to the ubiquitous POT (Tsay et al., 2007)

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The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

doi: 10.1016/j.freeradbiomed.2019.01.016 247 SchmittB.VicenziM.GarrelC.DenisF