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Zero adverse events Despite the invasive nature of the procedure (1,890 needle perforations per second at 2 mm depth), no adverse reactions were reported

This suggests that other dietary factors, outside of glutamate, such as the increased consumption of antioxidants and micronutrients protective against excitotoxicity, may either alternatively be responsible for the widespread improvement in psychiatric symptoms observed in this study, and/or may be protecting against negative effects from glutamate exposure during the challenge period

During investigations into HUA complications, MSU crystals were observed to induce fibrosis and expedite the progression of hyperuricemic nephropathy, unlike sUA (17)

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