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Hepatology 50 , 861870 (2009)

[19] [21] The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, including chemotherapeutic agents and other drugs, pesticides, herbicides, carcinogens, and variably-derived epoxides

SLC39 proteins increase the cytoplasmic zinc concentration importing the ion in when cellular concentration is depleted ( The effectiveness of zinc supplementation in people with trisomy 21 has been reported with discordant results

This makes the toxin more water soluble then transports it to bodys elimination system

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