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Additionally, P53 can inhibit cystine uptake through downregulation of SLC7A11 expression within the Xc system, affecting GPX4 activity which leads to reduced cellular antioxidant capacity, accumulation of lipid ROS, and ferroptosis [32, 33]

ROS-Glo H 2 O 2 assay H 2 O 2 induction in HepG2 and HepG2 ATP7B-KO cells after CuCl 2 treatment was performed by ROS-GLO H 2 O 2 Assay (Promega) according to manufacturers instructions

Furthermore, the ALA and GLA groups demonstrated improvements in quality of life

El agotamiento de GSH tambin representa un factor clave en la activacin de la inflamacin autnoma celular, como en los tejidos musculares adiposos y esquelticos envejecidos

doi:10.1172/JCI146071 7

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