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As a form of metabolic reprogramming, dysregulated SHMT-mediated one-carbon metabolism has been increasingly reported in various human cancers and liver metabolic diseases

Statin-induced selective downregulation of selenoprotein (including GPX4) expression leads to increased sensitivity of hepatocytes to peroxides by preventing mevalonate-dependent maturation of a single human Sec-tRNA [191]

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In other words, as the concentration of the analyte increases or decreases, the response of the method should increase or decrease in a linear manner