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Mitophagy is impaired in HF, causing the accumulation of damaged mitochondria, due in part to reduced PGC-1 expression, and overexpression of PGC-1 restores mitochondrial function and cardiac performance in HF models [18]
Research in aged primates demonstrates that Epithalon administration significantly increases nighttime melatonin levels in senescent monkeys while showing minimal effects in young animals, indicating specific targeting of age-related dysfunction
More research is needed to understand the nuanced differences between the early and late forms of the disease
