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Therefore, the following supplemental tables present key studies that highlight the major roles of CHAC proteins (Supplementary Tables S1S6)
In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)
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At the level of glucose metabolism, the hosts glucose homeostasis is a key guarantee for the survival of immune cells during C
Immunol Rev 266(1):7292 Wang C, Liu Q, Huang Q, Liu J, He Y, Lu J, Bai X (2013a) Activation of PPAR is required for hydroxysafflor yellow A of Carthamus tinctorius to attenuate hepatic fibrosis induced by oxidative stress
