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Additionally, maternal and post-weaning HFD exposures affect mitochondrial dynamics (e.g., MFN2, MFF), lower antioxidant defenses (SOD, catalase), and elevate oxidative stress markers such as MDA, leading to reduced primordial follicle counts and impaired folliculogenesis (Yan et al., 2020)

Consistently, Rho0 cells, which lack functional ETC, were more sensitive to GPX4 inhibitionmediated mitochondrial lipid peroxidation and ferroptosis than control cells

5 Mechanisms of OS-mediated pathological changes in the endometrium OS may serve as a pivotal link between obesity and endometrial pathology, and is one of the factors promoting the onset and progression of endometrial diseases