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These CAFs release proteins that build up a dense, fibrous environment around the tumor, creating a lowoxygen, or hypoxic, setting that makes chemotherapy less effective

& Gamelli, R

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This has been a major challenge for the development of treatment options, since only 30% of patients with MDD who receive an adequate treatment experience full remission (1)

Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-B