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Troubleshooting inadequate response If weight loss is minimal after 12-16 weeks at therapeutic doses, evaluate several factors

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The first trial, published in 1990 (159), was the only one to tick all the boxes in the report under the Cochrane banner (1) : an attempt to gauge quality-of-life used questionnaires based on patients with chronic backache, inappropriate in retrospect but the best available at the time

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