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This severe glutamine deprivation leads to dramatic histone hypermethylation due to decreased -KG levels subsequent to decreased activity of Jumonji domain-containing histone demethylases and results in cancer cell dedifferentiation and resistance to BRAF inhibitors 103

Knechtle B, Nikolaidis PT

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Treatment is typically prescribed according to the underlying cause

The NUHS Internal Grant Funding under NUS starts-up grant NUHSRO/2022/047/Startup/11 and an MOE Tier 2 grant T2EP30124-0014

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