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Targeting this axis with resveratrol provides a promising combinatorial strategy to overcome chemoresistance

ID8 Trp53 / model of ovarian cancer For the ovarian cancer experiments, C57BL/6J female mice (67 weeks old) were purchased from Charles River Laboratories UK (RRID: IMSR_JAX:000664) and allowed to acclimatize for at least 1 week before any regulated procedures were performed

[PubMed: 7593445] 481

Cellular Senescence and Aging Research Senescent cells accumulate naturally with age and contribute to: Chronic inflammation Tissue dysfunction Reduced regenerative capacity Biological aging Research involving FOXO4-DRI investigates its potential role in selectively clearing these dysfunctional cells to support healthier tissue environments

Jabbour HN (2009) Vascular function in female reproduction