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Our study demonstrated that Gln deprivation severely inhibited the tumor growth of HCC and PCa both in vivo and in vitro, and this occurs partially through reduced GSH levels, resulting in ROS accumulation

In OA models, ACSL4 inhibition dramatically decreases ferroptosis-associated lipid peroxidation (77)

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7f), and, in colonic mucosal samples, in 14.6% of children in the USA in a study of inflammatory bowel disease and 63.2% of adults in Australia in a study of colorectal cancer (Fig

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16 Dysregulated mitochondrial ROS production is a feature of smokers with COPD 17,18 that is not limited to the lungs