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In this sense, previous in vitro studies performed by our research group have shown that co-administration of conventional chemotherapeutic agents with antioxidants such as melatonin enhances chemotherapeutic-induced cytotoxicity and apoptosis in different cancer cell lines (Uguz et al., 2012
In research on rats exposed to cobalt chloride, luteolin revealed an overproduction of H 2 O 2 and MDA, as down-regulation of key antioxidant enzymes, including GPX, SOD, and glutathione- S -transferase (GST), to inhibit damage to Purkinje neurons in the cerebellum
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Salimi A et al (2019) Maternal exposure causes mitochondrial dysfunction in brain, liver, and heart of mouse fetus: an explanation for perfluorooctanoic acid induced abortion and developmental toxicity
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