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This is the reason that many B12 supplements (whether they are in a pill form or even a tincture taken sublingually) often have 16,000%+ of your daily recommended intake of B12 in a single serving

B12 B12 injections are commonly prescribed and often for many years, to fulfil 2 key functions - reverse B12 deficiency, especially if severe

Maybe all three

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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Oshima H., Rochat A., Kedzia C., Kobayashi K., Barrandon Y