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Thyroid (1998) 8(4):3538

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Green nanomaterials can be synthesized via biological or green routes using microorganisms such as bacteria, fungi, algae, and plant extracts, which act as reducing and stabilizing agents [110, 111]

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At physiological concentrations, ROS is important to cellular division, but excessive ROS leads to stressed damages to protein, DNA and lipid (Szczepanowska et al., 2012

For studies of IGF1R signaling itself, that is a feature, not a limitation