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The FDA has approved five anti-TNF drugs for AS, but doctors tend to prescribe either adalimumab ( Humira ) or infliximab ( Remicade ) first

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A specific NSAID, celecoxib, affected firstly the lower esophageal sphincter, and then, after a day, the pyloric sphincter as well

I've put together a full literature review, all the key papers, mechanism data, TGA and FDA regulatory status, and safety profile