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This adrenal circadian clock appears to gate the response to ACTH, i.e

When each resistant population was treated with MCFG, CO23RFK cells showed a moderate decrease of GSH/GSSG ratio indicating a slight oxidative stress while CO23RFLC cells were dramatically affected in the their oxidative state

[DOI] [PubMed] [Google Scholar] 191.de Fays L, Van Malderen K, De Smet K, et al

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