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Furthermore, DC32 induces p62 expression through the Nrf2-P62-Keap1 feedback loop, effectively impeding the progression of RA

doi: 10.1080/23311932.2025.2519800 120

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Functional experiments confirmed that knocking down p21 expression in a DMM surgery-induced mouse OA model exacerbated articular cartilage degradation and was accompanied by a significant decrease in GPX4 protein levels in vivo , demonstrating that p21 plays an important anti-ferroptotic role in OA progression by modulating GPX4 stability (Zheng et al., 2024)