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10.3390/biom10091219 [DOI] [PMC free article] [PubMed] [Google Scholar] Itzkowitz, S

Injection Site Strategy Targeting an injury

The lower intracellular levels of serine and glycine in cancer cells that we observed in vitro indicate a high turnover with increased consumption and usage of these amino acids in downstream biosynthetic pathways, which is supported by the enhanced SHMT2 expression in response to RT

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When purified protein was incubated with the gels (Figure 2), a significant decrease in GST-GFP was found in the solution after two hours compared to gel-free controls in the 1:1 (p = 0.008), 5:1 (p = 0.005), 20:1 (p = 0.02), 40:1 (p = 0.02), and 80:1 (p = 0.02) PEGDA to glutathione ratio gels (Figure 2A)

Its a very attractive target, says Amy Keating, an MIT professor of biology and one of the senior authors of the study