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Ferroptotic agents induce endoplasmic reticulum stress to promote PUMA expression through the PERK-eIF2-ATF4-CHOP pathway (73), but this form of PUMA does not lead to cell apoptosis

2010 Apr-Jun;28(2):120-3

Vitamin C injections are generally well tolerated at medically appropriate doses, but high doses can lead to iron overload, kidney stones, and kidney damage

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Los estudios preclnicos sugieren una interaccin funcional con los receptores GABA-A, aunque el mecanismo molecular preciso requiere mayor investigacin