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NMDA Receptor Modulation Mechanism MK-801 studies (MK-801 is a more selective NMDA antagonist) showed BPC-157 counteracted locomotion abnormalities, stereotyped sniffing, and ataxia

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With limited ability to expand due to the confines of the intracranial compartment, there is an increase in intracranial pressure and a reduction in perfusion and oxygenation, giving rise to additional ischemic damage

These interactions can exacerbate the inflammation [114]